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STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA
STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA
The present invention describes a flexible basestacking monomer that can beincorporated into an oligonucleotide or oligonucleotide analogue, as well astriplex forming oligonucleotides comprising the flexible basestacking monomer.Triplex forming oligonucleotides of the invention are capable of bindingsequence specifically to doublestranded target nucleic acids and are thereforeof interest for modulation of the activity of target nucleic acids and alsodetection of target nucleic acids.
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