Free-Radical Version of the Strecker Synthesis of alpha-Aminoamides Promoted by Aqueous H_2O_2/TiCl_3/HCONH_2 System

摘要

The development of new methods for the synthesis of natural and unnatural alpha-amino acid derivatives is an area of current interest both in synthetic and medicinal chemistry.Although many valuable multistep routes to alpha-amino acid precursors are available,syntheses of these compounds by one-pot multicomponent reactions(MCRs)are particularly fascinating since they facilitate rapid construction of very large compound libraries which can,then,be used for drug discovery.