Dinuclear Zn-Catalyzed Asymmetric Alkynylation of Unsaturated Aldehydes

摘要

Our recent development of the proline-derived bimetallic catalyst system 1 has led to a number of efficient,catalytic,enantio-selective transformations,including the asymmetric Henry and Mannich reactions,desymmetrization of meso l,3-diols,and the direct aldol reaction of traditionally difficult substrates,including both ynones and methylvinyl ketone.