Crystallographic Characterization of the α/β-Peptide 14/15-Helix

摘要

The search for oligomers that adopt specific conformations ("foldamers") has recently included many efforts to identify backbones containing more than one class of subunit. Combinations involving α- and β-amino acids have been especially popular, and other systems have been examined as well. In early studies, we found that folding of short α/β-peptides with a 1:1 alternation of a- and β-residues is promoted by β-residues that have a five-membered ring constraint, such as trans-2-aminocyclopentanecar-boxylic acid (ACPC).