Transition-State Structure of Neisseria meningitides 5'-Methylthioadenosine/ S-Adenosylhomocysteine Nucleosidase

摘要

5'-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) is a bacterial enzyme of the Af-ribosyltransferase family. It catalyzes the biologically irreversible hydrolytic deadenylation of 5'-methylthioadenosine (MTA) or S-adenosylhomocysteine to form adenine and methylthioribose (MTR) or S-ribosylhomo-cysteine, respectively (Figure 1). MTAN is involved in bacterial quorum sensing pathways and thus is a potential target for the design of antibiotics.