Active Trifluoromethylating Agents from Well-Defined Copper(l)-CF_3 Complexes

摘要

Fluorocarbons are becoming increasingly important in the medicinal, materials, and agricultural fields. The ability of fluorinated molecules to modulate biological functions may not be surprising at first glance, as fluorine ranks 13th on the most naturally abundant elements list. However, only a handful of naturally occurring fluoroorganic molecules have ever been reported.5 Thus, the vast majority of organofluorine compounds are manmade. Consequently, synthetic methodology to incorporate fluorine and fluorous synthons must be improved in order to prepare sophisticated fluoroorganic molecules on a practical scale. There is an incredible commercial driving force for improving fluorination reactions, as three of the top eight selling drugs in 2007 contained fluorine, including two out of the top three.