A Strategy for C-H Activation of Pyridines: Direct C-2 Selective Aikenylation of Pyridines by Nickel/Lewis Acid Catalysis

摘要

A large number of Pharmaceuticals, natural products, and optical materials contain a pyridine nucleus. Thus, the functionalization of pyridines is an important transformation in organic synthesis. However, due to the low reactivity of pyridine derivatives toward aromatic electrophilic substitution reactions such as the Friedel-Crafts reaction, additional steps including halogenation and meta- lation are required to install substituents in a pyridine ring.