PURPOSE: To synthesize orthohalogenated pyridine carboxylic acid or pyridine carboxylic acid amide that is important as a synthetic intermediate of medical products or plant disinfectants. ;CONSTITUTION: Orthohalogenated pyridine carboxylic acid is obtained by reacting hologenated pyridine with organic lithium derivative and then with carbon dioxide and subsequently by acidifying the reacting solution after hydrolysis. Organic lithium derivative is selected from the group consisting of alkyl- lithium, aryl-lithium, or N,N-2 substituted aliphatic lithium amide. X-carboxy or carboxyamide-(X+1)-fluoropyridine (X is 2 or 3), 3-carboxy or carboxyamide-4-trifluoromethyl-2-halo genopyridine, 3-carboxy or carboxyamide-2,4-dihalogenopyridine are new compounds.;COPYRIGHT: (C)1993,JPO
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