Small Molecule-Based Binding Environments: Combinatorial Construction of Microarrays for Multiplexed Affinity Screening

摘要

The preparation of stable and diverse binding agents in an addressable format is an objective with myriad applications in proteomics, diagnostics, pharmaceutical development, and related fields. Significant advances toward this aim have been made, and among them microarray-based technologies stand out on the basis of a high-throughput and miniaturized format. In particular, small molecule microarrays (SMMs) have contributed to the expansion of our capabilities in high-throughput screening.