A Mammalian Reductive Deiodinase has Broad Power to Dehalogenate Chlorinated and Brominated Substrates

摘要

Halogenated compounds and solvents have great economic value but pose long-term threats to the environment. Chlorinated compounds in particular resist microbial degradation and accumulate in soil and water. Only a limited number of organisms have demonstrated an ability to metabolize such compounds and hence have become central to developing biological methods of remediation. Anaerobes contribute significantly to this process by catalyzing reductive dehalogenation.A number of catalytic strategies utilizing a range of cofactors are associated with these processes. For example, both cobalamin and Fe/S-centers are involved in the reductive dechlorination of tetrachloroethene and chlorophenol. Porphyrins, factor F430, ferredoxins, and even flavin may also participate in various other reductive dechlorinations although no direct role for flavin has yet to be established.