Palladium-Catalyzed Carboamination of Alkenes Promoted by N-Fluorobenzenesulfonimide via C-H Activation of Arenes

摘要

The intramolecular oxidative difunctionalization of alkenes is a powerful method for the introduction of diverse functional groups into organic molecules. Simultaneous formation of C-N and C-C bonds from an olefin (carboamination) is particularly appealing, in part because of the rarity of this transformation. Pd-catalyzed aminocarbonylation of alkenes using CO as the carbon source was extensively developed by Hegedus and Tamaru. Wolfe has shown that aryl bromides can be used to form C-C bonds via Pd-cataiyzed carboamination of aminoalkenes.