Concise Enantioselective Synthesis Of Ent-malbrancheamide B

摘要

There is a growing family of fungi-derived alkaloids whose members feature a bicyclo[2.2.2]diazaoctane core as part of a more complex polycyclic structure. Important examples include brevi-anamide B (1), paraherquamide A (2), stephacidin A (3), and the most recently added members of the group, the malbrancheamides 4 and 5 (Figure I).rnThese compounds combine synthetically challenging structures, intriguing biosynthetic origins, and, in many cases, potent biological activities. The malbrancheamides, recently isolated from the fungus Malbranchea aurantiaca, are unique in having a chlorinated indole nucleus, and compound 4 was shown to be a new calmodulin (CaM) inhibitor.