Electronic Effects on Atom Tunneling: Conformational Isomerization of Monomeric Para-Substituted Benzoic Acid Derivatives

摘要

We present the first generation and spectroscopic identification of the higher-lying E conformer of the simplest aromatic carboxylic acid, benzoic acid (1a), as its O-deuterated isotopologue (E)-d_1-1a using matrix-isolation techniques; the parent (E)-1a could not be observed because of fast H-tunneling to the more stable conformer (Z)-1a. Even deuterated (E)-d_1-1a converts quickly back to (2)-d_11a through D-tunneling with a half-life (t) of ～12 min in Ar at 11 K. Tunneling computations using an Eckart barrier in conjunction with a CCSD(T)/cc-pVTZ//MP2/ cc-pVDZ + ZPVE intrinsic reaction path revealed that τ of (E)-1a is only ～10~(-5) min, in marked contrast to those of simple aliphatic acids, which are in the range of minutes. The electronic substitu-ent effects on D-tunneling in para-substituted benzoic acid derivatives (p-X-PhCOOD, d_1-1) were systematically studied in Ar matrices at 11 K to derive the first Hammett relationships for atom tunneling. σ-Electron donors (X = alkyl) increase the half-life of d_1-1, while σ-acceptor/,π-donor groups (X = OD, NH_2, halogen) and to an even greater extent a σ-/π-acceptor group (X = NO_2) decrease τ. The latter finding is in line with the smaller E-to-Z reaction barriers and narrower reaction widths for the isomerization. Tunneling substituent constants (σ~t) for this conformational isomerization were derived experimentally and computationally.