Gold-Catalyzed One-Step Practical Synthesis of Oxetan-3-ones from Readily Available Propargylic Alcohols

摘要

Oxetan-3-ones contain a strained four-membered ring and possess considerable synthetic/medicinal utility. They have been incorporated into steroid skeletons, used to prepare oxetanocin derivatives, and converted into 3-aminooxetanes including 3-ami-nooxetane-3-carboxylic acid. Moreover, Rogers-Evans, Carreira and co-workers have shown that the oxetane ring can serve as a surrogate of a gem-dimethyl group, resemble a carbonyl group, and offer alternatives to 1,3-heteroatom-substituted cyclohexanes in spirocyclic structures in drug discovery; in these studies, the parent oxetan-3-one serves as an essential starting material for introducing the oxetane ring.