Asymmetric Synthesis of All-Carbon Quaternary Stereocenters via Desymmetrization of 2,2-Disubstituted 1,3-Propanediols

摘要

Enantioselective desymmetrization of symmetric molecules is an economical way to generate chirality. The process is effected by differentiation of two enantiotopic groups and is advantageous due to the relatively facile preparation of the starting substrates. Among the stereogenic carbon centers, the formation of quaternary centers directly bonded to heteroatoms or all-carbons is particularly challenging.