Dynamic Chirality of (E)-5-Cyclononen-1-one and its Enolate

摘要

It has been found that (E)-5-cyclononen-l-one (2a) exhibits marginal planar chirality owing to an insufficient topological constraint, whereas the enolates 3 derived from 2a show robust planar chirality. Enantioen-riched enolates are easily prepared by enzymatic hydrolysis, and they show an ability to serve as chiral nucleophiles.