Diastereoselective aldolization with reputed unstable enolates : Synthesis of chiral α-amino-β-hydroxy acids , aminodiols or diaminoalcohols

摘要

Syn α-Amino-β-hydroxy acids are the key structures of many natural products exhibiting a wide range of biological activities. For example, syn α-amino-β-hydroxy acids are found in vancomycin or polyoxins (antibiotics), cyclomarins (cytotoxic, antiinflammatory), ustiloxins (antibiotic, antimitotic), and exochelins (iron chelator). Many studies have been devoted to the synthesis of this unit and most of them rely on an aldol reaction between a glycine equivalent and an aldehyde.