机译:富含卤素的片段文库作为p53突变药物抢救的先导
Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls-University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany,MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, United Kingdom;
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, United Kingdom;
Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls-University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany;
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, United Kingdom;
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, United Kingdom;
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, United Kingdom;
Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls-University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany;
机译:富含卤素的片段库,作为在基于片段的铅发现中利用卤素键的化学探针
机译:利用氟硫接触和多极相互作用设计p53突变型Y220C救援药物
机译:通过计算机筛选的药物靶向修复p53不稳定的突变体
机译:信息丰富的p53癌症抢救突变体的主动学习框架
机译:致癌,抑制和挽救的p53核心域突变体的晶体结构表明了整体抑制突变的挽救机制
机译:在基于片段的药物发现中拥抱卤素键基序的多样性-构建多样性优化的富含卤素的片段文库
机译:富含卤素的片段文库作为p53突变药物抢救的先导
机译:用小分子化合物药理学拯救突变型p53的结构基础。