Pd(Ⅱ)-Catalyzed Enantioselective C-H Activation/C-O Bond Formation: Synthesis of Chiral Benzofuranones

摘要

Pd(Ⅱ)-catalyzed enantioselective C-H activation of phenylacetic acids followed by an intramolecular C-O bond formation afforded chiral benzofur-anones. This reaction provides the first example of enantioselecctive C-H functionalizations through Pd-(Ⅱ)/Pd(Ⅳ) redox catalysis.