Remote Control of Axial Chirality: Aminocatalytic Desymmetrization of N-Arylmaleimides via Vinylogous Michael Addition

摘要

Remote control of the axial chirality of N-(2-t-butylphenyl)succinimides was realized via the vinylogous Michael addition of 3-substituted cydohexenones to N-(2-t-butylphenyl)maleimides. 9-Amino(9-deoxy)epi-qui-nine promoted the enantioselective desymmetrization, leading to atropisomeric succinimides with two adjacent stereocenters.