Spotlights on Recent JACS Publications

摘要

In the tightly woven ever-shifting environment of the chromosome, getting proteins to fold correctly and find their binding partners is critical. That is where chaperones come in. Garegin Papoian, Yamini Dalai, and colleagues perform molecular dynamics simulations and in vivo experiments investigating the interactions between the centromere-specific chaperone, Holliday Junction Recognition Protein (HJURP), and histone proteins, which manage genetic material in human chromosomes (DOI:10.1021/jacs.6b05355). Their findings suggest that chaperones not only facilitate folding but also can promote correct interactions between histones themselves.