Spotlights on Recent JACS Publications

摘要

Using rheology NMR (Rheo-NMR) spectroscopy, Kenji Sugase and co-workers provide an unprecedented view into the formation of protein aggregates that are a hallmark of Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) (DOI: 10.1021/jacs.1c02974).The aggregation of some proteins in the brain into oligomers-and eventually into amyloid fibrils-may contribute to toxicity and disease in people with AD and ALS. But so far, researchers have struggled to track the formation of these aggregates in situ at fine enough resolution to understand the molecular mechanisms that drive it.