Synthesis and antibacterial activity of some novel p-(N-benzoyl) aminobenzoic acid derivatives

摘要

Reaction of p-(Nbenzoyl) aminobenzoic acid (Ⅰ) with PCl_5 furnished the acid chloride (Ⅱ) which was reacted with amines, hydrazine and hydroxy compounds to give the corresponding amide (Ⅲ-Ⅸ), hydrazide (Ⅹ) and ester (Ⅺ-XV) derivatives, respec- tively. 1-[p-(N-Benzoyl) aminobenzoyl]-3-methyl-4-substituted-phenyl-6-imino4-, 7- dihydro-1,3-thiazino [5,4-d] pyrazolones (XXIII-XXV) have been synthesized by the condensation of 1[p-(N-benzoyl) aminobenzoyl]-4-arylideno-3-methyl-5-pyrazolones (XX-XXII) with thiourea in methanolic KOH.