MIXED ANHYDRIDES OF QUINOLINECARBOXYLIC ACID AND BORIC ACID AS INTERMEDIATE PRODUCTS FOR SYNTHESIS OF PIPERAZINYL-3-QUINOLINECARBOXYLIC ACID DERIVATIVES SHOWING ANTIBACTERIAL ACTIVITY

摘要

use: as intermediate products in the synthesis of the derivatives of pipe - u0440u0430u0437u0438u043du0438u043b - 3 - u0445u0438u043du043eu043bu0438u043du043au0430u0440u0431u043eu043du043eu0432u043eu0439 acid with u0430u043du0442u0438u0431u0430u043au0442u0435u0440u0438u0430u043bu044cu043du043eu0439 activity.the essence of the u0438u0437u043eu0431u0440u0435u0442u0435u043du0438u00a0: product invention u043eu0442u043du043eu0441u0438u0442u0441u00a0 new derivative of general formula mixed u0430u043du0433u0438u0434u0440u0438u0434u043eu0432 quinoline - carbon acid and boric acid to the total s u043eu0440u043cu0443u043bu044b i where r is u0446u0438u043au043bu043eu043fu0440u043eu043fu0438u043b, a group of general formula CH2CR5R6R rs, where r is hydrogen, halogen, u0444u0435u043du0438u043b. 4 - u0433u0430u043bu043eu0433u0435u043du0444u0435u043du0438u043b, 2.4 - u0434u0438u0433u0430u043bu043eu0433u0435u043du0444u0435u043du0438u043b or 3.4 - u0434u0438u0433u0430u043bu043eu0433u0435u043du0444u0435u043du0438u043b; ri and r2 is halogen or u0430u043bu0438u0444u0430u0442u0438u0447u0435u0441u043au0430u00a0 and u0446u0438u043bu043eu043au0441u0438u0433u0440u0443u043fu043fu0430, u0441u043eu0434u0435u0440u0436u0430u0449u0430u00a0 from 2 to 6 carbon atoms; u0439u0437 is chlorine or fluorine; r4 is hydrogen or fluorine. the reactant product of the general formula i: COOfy u0433u0434u0435u04401, R3.R4 have the u0437u043du0430u0447u0435u043du0438u00a0; Rg hydrogen or the keel, containing 1 to 4 carbon atoms.reagent ii: u0442u0435u0442u0440u0430u0444u0442u043eu0440u0431u043eu0440u043du0430u00a0 acid or u0442u0440u0438u0433u0430u043bu043e - u0438u0434u043du044bu0439 bohr u0432u0445u0437, where x is fluorine, chlorine or bromine or its ether compound or a derivative of the common forms of u0442u0440u0438u0430u0446u0438u043bu043eu043au0441u0438u0431u043eu0440u0430u0442u043du043eu0435 ula b (OCORg) 3, where Rg - u0430u043bu043au0438u043b containing 1 to 5 carbon atoms and u043du0435u043eu0431u00a0u0437u0430u0442u0435u043bu044cu043du043e u0437u0430u043cu0435u0449u0435u043du043du044bu0439 u0433u0430u043bu043eu0433u0435u043du043eu043c or u0430u0440u0438u043b containing 6 to 10 carbon atoms. l with with the 00 with sa on yu cj fO