Phase II trial of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of anaplastic astrocytoma

Ji H. Kim; Linna Li; Tony S. Quang; Jacqueline G. Emrich; Theodore E. Yaeger; Joseph M. Jenrette; Steven C. Cohen; Perry Black; Luther W. Brady

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Phase II trial of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of anaplastic astrocytoma

机译：表皮生长因子受体放射免疫疗法治疗间变性星形细胞瘤的II期试验

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Objective The efficacy and safety of adjuvant radioimmunotherapy with 125I-labeled anti-epidermal growth factor receptor 425 murine antibody (125I-425 mAb) in patients with newly diagnosed anaplastic astrocytoma (AA) is evaluated in this single-institution phase II study.

机译：目的在该单机构II期研究中，评估125I标记的抗表皮生长因子受体425鼠抗体（125I-425 mAb）辅助放射免疫疗法对新诊断的间变性星形细胞瘤（AA）患者的疗效和安全性。

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来源
《Journal of Radiation Oncology》 |2013年第1期|7-13|共7页
作者
Ji H. Kim; Linna Li; Tony S. Quang; Jacqueline G. Emrich; Theodore E. Yaeger; Joseph M. Jenrette; Steven C. Cohen; Perry Black; Luther W. Brady;
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作者单位

Radiation Oncology City of Hope National Medical Center">(1);

Radiation Oncology Bryn Mawr Hospital">(2);

Radiation Oncology VA Puget Sound Health Care System/Washington University">(3);

Radiation Oncology Drexel University College of Medicine">(4);

Radiation Oncology Wake Forest University School of Medicine">(5);

Radiation Oncology Medical University of South Carolina">(6);

Hematology and Oncology Bryn Mawr Hospital">(7);

Neurosurgery Drexel University College of Medicine">(8);

Radiation Oncology Drexel University College of Medicine">(4);

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正文语种 eng
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关键词
Radioimmunotherapy; Anaplastic; Astrocytoma; Anti-epidermal growth factor receptor; 125iodine-labeled monoclonal antibody 425; Glioma; Monoclonal antibody;

机译：放射免疫疗法;间变性星状细胞瘤抗表皮生长因子受体;125碘标记的单克隆抗体425;胶质瘤;单克隆抗体;

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1. Corneal verticillata after dual anti-epidermal growth factor receptor and anti-vascular endothelial growth factor receptor 2 therapy (vandetanib) for anaplastic astrocytoma. [J] . Yeh S, Fine HA, Smith JA Cornea . 2009,第6期

机译：抗角质层星形细胞瘤的双重抗表皮生长因子受体和抗血管内皮生长因子受体2（vandetanib）治疗后的角膜黄斑病。
2. A Phase II study of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme. [J] . Li L, Quang TS, Gracely EJ, Journal of neurosurgery. . 2010,第2期

机译：抗表皮生长因子受体放射免疫疗法治疗多形性胶质母细胞瘤的II期研究。
3. A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor monoclonal antibody in the treatment of newly diagnosed adult glioblastoma [J] . Westphal Manfred, Heese Oliver, Steinbach Joachim P., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2015,第4期

机译：尼莫妥单抗是一项抗表皮生长因子受体单克隆抗体的随机，开放标签III期临床试验，用于治疗新诊断的成年胶质母细胞瘤
4. Application of a Molecularly Imprinted Polymer for the Effective Recognition of Different Anti-Epidermal Growth Factor Receptor Inhibitors [C] . 北京大学中医药现代研究中心2003年年会论文集 . 2004

机译：分子印迹聚合物在有效识别不同抗表皮生长因子受体抑制剂中的应用
5. I. Distribution of transforming growth factor beta 1, TGF receptor II and decorin in the sheep uterus shortly after breeding. II. Effect of TGF beta 1 on gene expression in the sheep uterus at the time of embryo attachment. III. Concentration of TGF beta 1, 2, and 3 in beef bull and ram seminal plasma. [D] . Holaskova, Ida. 2007

机译：一，繁殖后不久，绵羊子宫中转化生长因子β1，TGF受体Ⅱ和decorin的分布。二。 TGF beta 1对胚胎附着时绵羊子宫中基因表达的影响。三，牛公牛和公羊精浆中TGF β1、2和3的浓度。
6. Phase II Trial of Cabozantinib Plus Erlotinib in Patients With Advanced Epidermal Growth Factor Receptor (EGFR)-Mutant Non-small Cell Lung Cancer With Progressive Disease on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy: A California Cancer Consortium Phase II Trial (NCI 9303) [O] . Karen L. Reckamp, Paul H. Frankel, Nora Ruel, 2007

机译：卡博替尼+厄洛替尼在晚期表皮生长因子受体（EGFR）-突变型非小细胞肺癌进展性疾病中进行表皮生长因子受体酪氨酸激酶抑制剂治疗的II期试验：加利福尼亚癌症协会II期试验（NCI 9303）
7. Phase II trial of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of anaplastic astrocytoma [O] . Ji H. Kim, Linna Li, Tony S. Quang, 2012

机译：抗表皮生长因子受体放射免疫疗法治疗厌备星形细胞瘤的II期试验

Phase II trial of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of anaplastic astrocytoma

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