Non-aqueous titrations as a tool in the study of molecular recognition phenomena. Uses in distinguishing hydrogen bonding from proton Transfer, the measurement of complex induced pK_a shifts, and the ability to distinguish the catalytic roles of gene

摘要

Whenever hydrogen bonding is involved in molecular recognition, the possibility of a proton transfer from the donor to the acceptor arises. In most cases the PK_a of the donor is far enough above the pK_a of the conjugate acid of the acceptor for it to be clear that no proton transfer will occur. However, as the difference between the donor and acceptor pK_as decreases, it can become difficult to predict whether a proton transfer will occur.