Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma

Katsuhiro Hayashi; Hiroyuki Tsuchiya; Norio Yamamoto; Toshiharu Shirai; Kensuke Yamauchi; Akihiko Takeuchi; Masami Kawahara; Ken-Ichi Miyamoto; Katsuro Tomita

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Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma

机译：监测咖啡因对骨肉瘤咖啡因强化化疗的不良反应和化疗反应的影响

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Caffeine can safely enhance the cytocidal effects of anticancer drugs through its DNA repair-inhibiting effect. We have demonstrated in several studies that caffeine-potentiated chemotherapy induces a high complete response rate in patients with osteosarcoma. The present study focused on monitoring and adjusting serum caffeine levels during caffeine-potentiated chemotherapy to reduce adverse effects.

机译：咖啡因可通过其DNA修复抑制作用安全地增强抗癌药的杀细胞作用。我们已经在几项研究中证明，咖啡因增强的化学疗法可在骨肉瘤患者中诱导很高的完全缓解率。本研究的重点是在咖啡因强化化疗期间监测和调整血清咖啡因水平，以减少不良反应。

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《Journal of Orthopaedic Science》 |2009年第3期|253-258|共6页
作者
Katsuhiro Hayashi; Hiroyuki Tsuchiya; Norio Yamamoto; Toshiharu Shirai; Kensuke Yamauchi; Akihiko Takeuchi; Masami Kawahara; Ken-Ichi Miyamoto; Katsuro Tomita;
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Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University 13-1 Takaramachi Kanazawa 920-8641 Japan;

Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University 13-1 Takaramachi Kanazawa 920-8641 Japan;

Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University 13-1 Takaramachi Kanazawa 920-8641 Japan;

Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University 13-1 Takaramachi Kanazawa 920-8641 Japan;

Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University 13-1 Takaramachi Kanazawa 920-8641 Japan;

Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University 13-1 Takaramachi Kanazawa 920-8641 Japan;

Department of Pharmacy Kanazawa University Hospital Kanazawa Japan;

Department of Pharmacy Kanazawa University Hospital Kanazawa Japan;

Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University 13-1 Takaramachi Kanazawa 920-8641 Japan;

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1. Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma. [J] . Hayashi K, Tsuchiya H, Yamamoto N Journal of orthopaedic science : . 2009,第3期

机译：血清咖啡因监测对骨肉瘤咖啡因强化化疗的不良反应和化疗反应的影响。
2. Less frequent monitoring of response in patients with advanced thoracic malignancies receiving palliative chemotherapy, does not adversely impact patient care [J] . Milner-Watts C. L., Kumar R., Gunapala R., Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2018,第期

机译：对接受姑息化疗的先进后胸部恶性肿瘤患者的反应频繁监测不利影响患者护理
3. Less frequent monitoring of response in patients with advanced thoracic malignancies receiving palliative chemotherapy, does not adversely impact patient care [J] . Milner-Watts C. L., Kumar R., Gunapala R., Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2018,第Suppla1期

机译：对接受姑息化疗的先进后胸部恶性肿瘤患者的反应频繁监测不利影响患者护理
4. Quantification of Osteosarcoma Mineralization on Plain Radiographs - Novel Software Applications to Assess Response to Chemotherapy [C] . Xiaochun Xu, Kimberley S. Samkoe, Megan E. Anderson, Conference on Optics and Ionizing Radiation . 2020

机译：骨质瘤矿化对尾部X线片的定量 - 新型软件应用评估化疗的反应
5. Ultrasound Medical Imaging Systems Using Telemedicine and Blockchain for Remote Monitoring of Responses to Neoadjuvant Chemotherapy in Women's Breast Cancer: Concept and Implementation [D] . Shubbar, Safa 2017

机译：使用远程医疗和区块链的超声医学成像系统，用于远程监测女性乳腺癌对新辅助化疗的反应：概念和实施
6. Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles [O] . HIROSHI NAKATA, TATSUHIKO MIYAZAKI, TOMOYUKI IWASAKI, -1

机译：使用新型Span 80纳米囊泡药物递送系统开发肿瘤特异性咖啡因的化学疗法
7. Development of Tumor-Specific Caffeine-Potentiated Chemotherapy Using Span 80 Nano-Vesicles DDS [O] . Tatsuhiko Miyazaki, Hiroshi Nakata, Keiichi Kato 2017

机译：使用跨度80纳米囊泡DDS的肿瘤特异性咖啡因调节化疗的发展

Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma

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