Efficient synthesis of 1,1'-binaphthyl and 2,2'-bi-o-tolyl-2,2'-bis(oxazoline)s and preliminary use for the catalytic asymmetric allylic oxidation of cyclohexene

摘要

Chiral C_2-symmetric bis(oxazoline)s have been usc- cessfully employed as ligands with various metals in numerous catalytic asymmetric processes. These include cyclopropanation, aziridination, allylic substitution, hydrosilylation, imine additions, Diels-Alder aldol, and Wacker-type cyclization reaction. In addition we and Pfalitz have recently used bis(oxazolne) copper complexes as catalysts for the asymmetric allylic oxida- tion of simple olefins using tert-butyl perbenzoate.