Novel use of substituted 1,4-dihydrobenz[d]p1,3]oxazin-2-ones in the synthesis of important aminomethyl o-nitroanilines

摘要

Multifunctional o-nitroanilines are important inter- mediates in the synthesis of a variety of nitrogen heterocycles. However, there are very few efficient the amino group, which give the corresponding peri position substitution in the resultant nitrogen hetero- cycle. Earlier, we standardized a novel method for the synthesis of benzylamine derivatives 2 with an amino- methyl side chain ortho to the amino group of the o-nitroaniline derivative via a modified Mitsunobu reac- tion (Scheme 1) starting from the substituted benzyl acohol 1.