Practival method for chemoselective formation of MTPA amide derivatives from amino alcohols and phenols

摘要

Recently, we reported that Mosher's MTPA (methoxy- (trifluoromethyl)phenylacetyl) technology colud be used to deduce the absolute configuration (as well as the enantiomeric excess) of cyclic amines. That work built upon earlier important studies by Rauk~2a,b and Braek- man.~2c MTPA esters and amides of chiral alcohols and primary amines, respectively, are well known.