Synthetic studies toward the reveromycins: asymmetric synthesis of the spiroketal segment of reveromycin B

摘要

The reveromycins A (1) and B (2) are recent examples of spiroketal-containing natural products isolated from a soil actinomycete belongint to the Streptomyces genus. Both 1 and 2 act as inhibitors of the mitogenic activity Of epidermal growth factor (EGF), while 1 also exhibits Antiproliferative activity against human tumor cell lines KB and K562 as well as antifungal activity. The gross Structures of 1 and 2 were deduced by spectroscopic Analysis, while the absolute configuration of 1 depicted Followed from chiroptical and spectroscopic analysis of Various degradation products.