Enantioselective Synthesis of the [6, 6] Spiroketal Core of Reveromycin A

摘要

Reveromycin A(1) belongs to a family of microbial polyketides with unusual structural features and biological activities. The structure of 1 is composed of a [6, 6] spiroketal core decorated with highly unsaturated side chains. As a prelude to the synthesis of 1, we present herein a short, efficient, and enantioselective synthesis of the C9-C21 fragment 5 (spiroketal core) of reveromycin A.