Yb（OTf）3促进的螺环吲哚类衍生物合成研究

摘要

以三氟甲磺酸镱(Yb(OTf)3)为催化剂,PEG-400为溶剂,靛红、β-环己二酮与丙二腈(或氰基乙酸乙酯)三组分于60℃反应30 min合成一系列螺环吲哚类衍生物,收率为87%~95%,其结构经1H NMR和13C NMR确证。 Yb(OTf)3/ PEG-400可回收套用五次。%A series of spiro[4H-pyran-oxindole] derivatives in yield of 87% ~ 95% was synthesized by the reaction of isatins, malononitrile or ethyl cyano-acetate, and 1,3-dicarbonyl compounds in the presence of cata-lytic amount of Yb(OTf)3 using PEG-400 as the solvent at 60℃ for 30 min. The structures were confirmed by 1 H NMR and 13C NMR. It is proven that Yb(OTf)3/ PEG-400 can be recycled for five times.