A Convenient New Synthesis of Benzo[a]pyrene

摘要

A convenient new synthesis of the ubiquitous environmental carcinogen benzo[a]pyrene (BaP) is described. In the key step, the method entails Suzuki coupling of naphthalene 2-boronic acid with 2-bromobenzene-1,3-dial-dehyde and requires only three steps. It is considerably shorter and simpler than the older methods and provides BaP in higher overall yield.