IMMUNOMIMETIC PEPTIDE OF CHEMICAL CANCEROGENS WITH SPECIFIC INTERACTION EFFECT ON ANTIBODIES OF BENZOαPYRENE AND BENZOαANTHRACENE

摘要

FIELD: medicine.;SUBSTANCE: peptide is obtained from phage peptide library including set of static peptides with length of 12 aminoacid residues, by affine selection of phage clones containing peptide capable of specific linking to antibodies of benzo[α]pyrene and benzo[α]anthracene. Peptide displays specific interaction effect on antibodies of benzo[α]pyrene and benzo[α]anthracene and features molecular weight of 1.3 kDa and registered aminoacid sequence LHLPHHDGVGWG encoded by nucleotide sequence SEQ ID NO:1.;EFFECT: application in medicine as a base for peptide medicine development for immunologic prevention of malignant tumours of humans.;4 dwg, 3 ex