Enantioselective Approaches to Potential MetAP-2 Reversible Inhibitors

摘要

Enantioselective deprotonation of 4-substituted cyclohex-anones and highly stereoselective conjugate addition of higher order mixed cuprates were the key steps in a concise synthesis of fumagalone-related molecules.The origin of the (low) biological activity of the new compounds as compared to fumagalone is briefly discussed.