General Approach to Glycosidase Inhibitors.Enantioselective Synthesis of Deoxymannojirimycin and Swainsonine

摘要

Deoxymannojirimycin (2) and swainsonine (4) have been syn-thesized from each enantiomer of the same bicyclic carbam-ate precursor 7.The key intermediate was prepared by a simple and efficient three-step synthesis involving RCM of the diene 8.