Synthesis and NMR experiments of (4,5,6-C-13)-deoxymannojirimycin. A new entry to C-13-labeled glycosidase inhibitors

摘要

The synthesis of (4,5,6-C-13)-deoxymannojirimycin is described. The route employed is based oil Sharpless asymmetric epoxidation of (1,2,3-C-13)(E)-2,4-pentadien-l-ol and uses ring-closing metathesis as a key step. The labeled compound may be easily used for protein-binding experiments using NMR spectroscopic methods. (c) 2007 Elsevier Ltd. All rights reserved.