Double Nucleophilic 1,2-Addition of Silylated Dialkyl Phosphites to 4-Phosphono-l-aza-l,3-dienes: Synthesis of γ-Phosphono-a-aminobisphosphonates

摘要

γ-Phosphono-a-aminobisphosphonates were synthesized from a new class of 4-phosphono-l-aza-l,3-dienes by the addition of dialkyl trimethylsilyl phosphites to these azadienes in the presence of acid. Depending on the steric demand of the group on nitrogen, double 1,2-addition or tandem 1,4—1,2-addition occurred.