Extending Pummerer Reaction Chemistry. Synthesis Studies in the Phakellin Alkaloid Area

摘要

The syntheses of (±)-dibromophakellstatin and, from this species, (±)-dibromophakellin are described. Oxidative cyclization of a phenylthiolated dihydrooroidin derivative triggered by a Pummerer reaction constitutes the key step in this biomimetic approach to this family of marine alkaloids.