The leucine rich repeat kinase 2 (LRRK2) G2019S substitution mutation Association with Parkinson disease, malignant melanoma and prevalence in ethnic groups in Israel

摘要

Background A single missense mutation (G2019S) in the leucine rich repeat kinase 2 (LRRK2) gene has been reported to be prevalent among Ashkenazi Jewish patients with Parkinson disease (PD). An association between malignant melanoma (MM) and PD was also recently reported. The nature of this association is still elusive.