Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids

Henry Hirschberg; Chung-Ho Sun; Bruce J. Tromberg; Alvin T. Yeh; Steen J. Madsen

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Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids

机译：并发热疗对神经胶质瘤球体的5-氨基乙酰丙酸介导的光动力治疗的细胞毒性作用增强。

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During photodynamic therapy (PDT) both normal and pathological brain tissue, in close proximity to the light source, can experience significant temperature increases. The purpose of this study was to investigate the anti-tumor effects of concurrent 5-aminolevulinic acid (ALA)-mediated PDT and hyperthermia (HT) in human and rat glioma spheroids.

机译：在光动力疗法（PDT）期间，正常的和病理的脑组织都在靠近光源的地方会经历明显的温度升高。这项研究的目的是研究人类和大鼠神经胶质瘤球体中同时存在的5-氨基乙酰丙酸（ALA）介导的PDT和热疗（HT）的抗肿瘤作用。

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《Journal of Neuro-Oncology》 |2004年第3期|289-299|共11页
作者
Henry Hirschberg; Chung-Ho Sun; Bruce J. Tromberg; Alvin T. Yeh; Steen J. Madsen;
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作者单位

Department of Neurosurgery RikshospitaletBeckman Laser Institute and Medical Clinic University of California;

Beckman Laser Institute and Medical Clinic University of California;

Beckman Laser Institute and Medical Clinic University of California;

Beckman Laser Institute and Medical Clinic University of California;

Department of Health Physics University of NevadaLas Vegas Cancer Institute University of Nevada;

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正文语种 eng
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关键词
5-aminolevulinic acid; glioma; hyperthermia; photodynamic therapy; spheroid; synergism;

机译：5-氨基乙酰丙酸;神经胶质瘤;体温过高;光动力疗法;球体;协同作用;

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1. Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids. [J] . Hirschberg H, Sun CH, Tromberg BJ, Journal of neuro-oncology. . 2004,第3期

机译：并发高温对神经胶质瘤球体的5-氨基乙酰丙酸介导的光动力疗法的细胞毒性作用增强。
2. Repetitive 5-aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids. [J] . Madsen SJ, Sun CH, Tromberg BJ, Journal of neuro-oncology. . 2003,第3期

机译：重复的5-氨基乙酰丙酸介导的对人神经胶质瘤球体的光动力治疗。
3. Repetitive 5-aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids [J] . Steen J. Madsen, Chung-Ho Sun, Bruce J. Tromberg, Journal of Neuro-Oncology . 2003,第3期

机译：重复的5-氨基乙酰丙酸介导的光动力疗法治疗人脑胶质瘤球
4. Photodynamic therapy of human glioma spheroids: a comparative study of the effectiveness of 5-aminolevulinic acid and its esters [C] . Steen J. Madsen, Chung-Ho Sun, Bruce J. Tromberg, Conference on Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy Ⅺ Jan 19-20, 2002 San Jose, USA . 2002

机译：人类神经胶质瘤球体的光动力疗法：5-氨基乙酰丙酸及其酯类功效的比较研究
5. The effect of 5-aminolevulinic acid based photodynamic therapy and photochemical internalization of bleomycin on the F98 rat glioma cell line. [D] . Kharkhuu, Khishigzaya. 2008

机译：基于5-氨基乙酰丙酸的光动力疗法和博来霉素的光化学内在化对F98大鼠神经胶质瘤细胞系的影响。
6. Metformin enhances the cytotoxicity of 5-aminolevulinic acid-mediated photodynamic therapy in vitro [O] . Tomohiro Osaki, Inoru Yokoe, Kiwamu Takahashi, -1

机译：二甲双胍增强5-氨基乙酰丙酸介导的光动力疗法的细胞毒性
7. 5-Aminolevulinic Acid-Mediated Photodynamic Therapy of Human Glioma Cells In Vitro [O] . Uanshu Ding, Ruxiang Xu, Xiaodan Jiang, 2004

机译：5-氨基乙酰丙酸介导人脑胶质瘤细胞体外光动力学治疗

Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids

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