Loss of Heterozygosity Analysis of Chromosome 17p13.1–13.3 and its Correlation with Clinical Outcome in Medulloblastomas

摘要

Cytogenetic and molecular genetic studies have shown that deletions on the short arm of chromosome 17 distal to p53 locus are the most common genetic events in medulloblastoma. We examined the occurrences and frequencies of allelic deletions on chromosome 17p13.1–13.3 by loss of heterozygosity (LOH) analysis to investigate the possible involvement of 17p13.1–13.3 in medulloblastoma development. We also performed survival analysis to determine whether LOH analysis of 17p13.1–13.3 can be used to predict prognosis in medulloblastoma.