Transmission of bovine albumin under controlled flux ultrafiltration

摘要

This work reports the transmission of bovine albumin using 50k MWCO, 100k MWCO and 0.2 um membranes under controlled fluxes and low transmembrane pressure. With the 50k MWCO membrane, the transmission remained low and when the flux was increased step by step, there was a sharp increase in transmission as the flux reached 50 1m~(-2)h~(-1). The concentration of bovine albumin was estimated at the membrane surface by the classical film theory and did not increase sharply. It is suggested that increasing extensional shear at the higher flux might change the conformation of BSA molecules.