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Household epidemic models with varying infection response

机译:感染反应不同的家庭流行病模型

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This paper is concerned with SIR (susceptible → infected → removed) household epidemic models in which the infection response may be either mild or severe, with the type of response also affecting the infectiousness of an individual. Two different models are analysed. In the first model, the infection status of an individual is predetermined, perhaps due to partial immunity, and in the second, the infection status of an individual depends on the infection status of its infector and on whether the individual was infected by a within- or between-household contact. The first scenario may be modelled using a multitype household epidemic model, and the second scenario by a model we denote by the infector-dependent-severity household epidemic model. Large population results of the two models are derived, with the focus being on the distribution of the total numbers of mild and severe cases in a typical household, of any given size, in the event that the epidemic becomes established. The aim of the paper is to investigate whether it is possible to determine which of the two underlying explanations is causing the varying response when given final size household outbreak data containing mild and severe cases. We conduct numerical studies which show that, given data on sufficiently many households, it is generally possible to discriminate between the two models by comparing the Kullback–Leibler divergence for the two fitted models to these data.
机译:本文涉及SIR(易感→受感染→已清除)家庭流行病模型,其中感染反应可能是轻度或严重的,反应类型也影响个体的传染性。分析了两种不同的模型。在第一种模型中,可能是由于部分免疫力而预先确定了个体的感染状态,而在第二种模型中,个体的感染状态取决于其感染者的感染状态以及该个体是否被内部感染所感染。或家庭之间的联系。第一种情况可以使用多种类型的家庭流行模型来建模,第二种情况可以通过我们用感染者依赖性严重性家庭流行模型来表示的模型进行建模。得出两种模型的大量人口结果,重点是在流行病一旦发生的情况下,在给定规模的典型家庭中,轻度和重度病例总数的分布。本文的目的是调查在给出包含轻度和重度病例的最终规模家庭暴发数据时,是否有可能确定两个基本解释中的哪一个引起不同的响应。我们进行的数值研究表明,给定足够多家庭的数据,通常可以通过将两个拟合模型的Kullback-Leibler散度与这些数据进行比较来区分这两个模型。

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