Release of sodium fusidate from glass-ionomer dental cement

摘要

Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound sodium fusidate. Sodium fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter x 2 mm depth) prepared. After curing for 1 hour at 37℃, specimens were placed in water and release of sodium fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of sodium fusidate was shown to occur by diffusion for each level of addition, as shown by M_t/M_∞ being linear with respect to √time in both cases. Diffusion coefficients were calculated as 4.4 × 10~(-8) cm~2 s~(-1) and 3.0 × 10~(-8) cm~2 s~(-1) for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the sodium fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total sodium fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.