模擬大腸ファントムを用いたCTコロノグラフィの画像評価: 再構成スライス厚が及ぼす影響について

摘要

Computed tomography colonography (CTC) is a robust and reliable imaging test of the colon. Recent studies show good sensitivity for the identification of nonpolypoid (flat) lesions as well. The purpose of this study was to determine the accuracy and reproducibility of a volume-rendering (VR) and virtual gross pathology (VGP) technique for detecting a polypoid lesion phantom by varying slice thickness. The scan of a simulated house-made phantom was performed using a 16-slice CT scanner with varying combinations of tube voltage (120 kVp), effective exposure (100 mAs), detector configuration (16×0.75 mm), rotation time (0.75 s), helical pitch (0.688， 0.938， 1.066 and 1.188), reconstruction kernel (A, B and C)， and section thickness/reconstruction interval (0.8/0.4, 1.0/0.5 and 1.5/0.75 mm). All image data were transferred to a three-dimensional workstation to assess multi-planar reformation (MPR), VR and VGP. Accuracy of volume measurement using the VR technique for quantitative analysis was compared using a paired t-test. Four radiological technologists also independently evaluated the visual score using the VGP technique for qualitative analysis, and their evaluations were compared using one-way analysis of variance with Fisher's protected least significant difference post-hoc test. There was a statistically significant difference in reproducibility between the three different slice thicknesses as to volume measurement and observer performance test (p＜0.01 and p＜0.05, respectively). Furthermore, the reproducibility improved when using thinner slices. In conclusion, VR and VGP techniques using a slice thickness of 0.8 mm made it possible to maintain accuracy and reproducibility when using CTC to detect polypoid lesions.%Computed tomography colonography(CTC)は，1990年頃から欧米で大腸がんスクリーニング検査への応用が研究されるようになり，2008年には米国がん協会などの合同ガイドラインにおいて，50歳以上の大腸がんの中リスク群スクリーニング検査のーつとして，5年にー回行われることが推奨されている.これによつて，今後大腸がんスクリーニング検査として普及することが予測される.