Underexpression of Mineralocorticoid Receptor in Colorectal Carcinomas and Association with VEGFR-2 Overexpression

Francesco Di Fabio; Carlos Alvarado; Agnieszka Majdan; Adrian Gologan; Linda Voda; Elliot Mitmaker; Lenore K. Beitel; Philip H. Gordon; Mark Trifiro

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Underexpression of Mineralocorticoid Receptor in Colorectal Carcinomas and Association with VEGFR-2 Overexpression

机译：大肠癌中盐皮质激素受体的低表达及其与VEGFR-2过表达的关系

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摘要

The human mineralocorticoid receptor (MR) is a steroid receptor widely expressed in colorectal mucosa. A significant role for the MR in the reduction of vascular endothelial growth factor receptor-2 (VEGFR-2) mRNA levels has been demonstrated in vitro. To evaluate a potential contribution of MR to colorectal carcinoma progression, we analyzed the expression of MR in relation to VEGFR-2.

机译：人盐皮质激素受体（MR）是在结肠直肠粘膜中广泛表达的类固醇受体。在体外已证明了MR在降低血管内皮生长因子受体2（VEGFR-2）mRNA水平中的重要作用。为了评估MR对大肠癌进展的潜在贡献，我们分析了与VEGFR-2相关的MR表达。

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来源
《Journal of Gastrointestinal Surgery》 |2007年第11期|1521-1528|共8页
作者
Francesco Di Fabio; Carlos Alvarado; Agnieszka Majdan; Adrian Gologan; Linda Voda; Elliot Mitmaker; Lenore K. Beitel; Philip H. Gordon; Mark Trifiro;
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作者单位

Department of Colon and Rectal Surgery Sir Mortimer B. Davis Jewish General Hospital Montreal Quebec Canada;

Lady Davis Institute for Medical Research Sir Mortimer B. Davis Jewish General Hospital 3999 Cote St. Catherine Road Montreal Quebec H3T 1E2 Canada;

Department of Endocrinology Sir Mortimer B. Davis Jewish General Hospital Montreal Quebec Canada;

Department of Pathology Sir Mortimer B. Davis Jewish General Hospital Montreal Quebec Canada;

Department of Endocrinology Sir Mortimer B. Davis Jewish General Hospital Montreal Quebec Canada;

Lady Davis Institute for Medical Research Sir Mortimer B. Davis Jewish General Hospital 3999 Cote St. Catherine Road Montreal Quebec H3T 1E2 Canada;

Department of Endocrinology Sir Mortimer B. Davis Jewish General Hospital Montreal Quebec Canada;

Department of Colon and Rectal Surgery Sir Mortimer B. Davis Jewish General Hospital Montreal Quebec Canada;

Department of Endocrinology Sir Mortimer B. Davis Jewish General Hospital Montreal Quebec Canada;

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正文语种 eng
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关键词
Colorectal cancer; Mineralocorticoid receptor; Vascular endothelial growth factor receptor-2; Angiogenesis;

机译：大肠癌;糖皮质激素受体;血管内皮生长因子受体-2;血管生成;

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专利

1. Underexpression of mineralocorticoid receptor in colorectal carcinomas and association with VEGFR-2 overexpression. [J] . Di-Fabio F, Alvarado C, Majdan A, Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract . 2007,第11期

机译：大肠癌中盐皮质激素受体的低表达及其与VEGFR-2高表达的关系。
2. Overexpression of the 67-kD laminin receptor correlates with tumour progression in human colorectal carcinoma. [J] . Sanjuan X, Fernandez PL, Miquel R, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 1996,第4期

机译：67 kD层粘连蛋白受体的过表达与人类大肠癌的肿瘤进展相关。
3. Overexpression of soluble vascular endothelial growth factor receptor 1 in colorectal cancer: Association with progression and prognosis. [J] . Yamaguchi T, Bando H, Mori T, Cancer science. . 2007,第3期

机译：大肠癌中可溶性血管内皮生长因子受体1的过表达：与进展和预后相关。
4. Mineralocorticoid and glucocorticoid receptors involvement in experimental thrombosis augmentation during acute aldosterone infusion in diabetic rats [C] . Szoka P., Gromotowicz-Poplawska A., Zakrzeska A., European Congress of Pharmacology . 2012

机译：矿物质激素和糖皮质激素受体参与在糖尿病大鼠急性醛固酮输注期间的实验血栓形成增强
5. Plasma aldosterone levels increase after cerebral ischemia, and mineralocorticoid receptor antagonism at the time of reperfusion reduces infarct size; the role of mineralocorticoid receptor antagonism on the inflammatory response post-stroke. [D] . Dams Ramos, Carla Maria. 2012

机译：脑缺血后血浆醛固酮水平增加，再灌注时盐皮质激素受体拮抗作用减少了梗塞面积；盐皮质激素受体拮抗作用对中风后炎症反应的作用。
6. Overexpression of neutrophil gelatinase-associated lipocalin and its receptor in colorectal carcinoma: Significant correlation with cell differentiation and tumour invasion [O] . ZHUO LV, LI-YAN XU, ZHONG-YING SHEN, -1

机译：中性粒细胞明胶酶相关脂质运载蛋白及其受体在结直肠癌中的过表达：与细胞分化和肿瘤浸润显着相关
7. Overexpression of neutrophil gelatinase-associated lipocalin and its receptor in colorectal carcinoma: Significant correlation with cell differentiation and tumour invasion [O] . ZHUO LV, LI-YAN XU, ZHONG-YING SHEN, 2010

机译：嗜中性粒细胞明胶酶相关脂质植物及其在结肠直肠癌中的受体的过度表达：与细胞分化和肿瘤侵袭的显着相关性

Underexpression of Mineralocorticoid Receptor in Colorectal Carcinomas and Association with VEGFR-2 Overexpression

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