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Comparison of the antipathogenic effect toward Staphylococcus aureus of N-linked and free oligosaccharides derived from human, bovine, and goat milk

机译:衍生自人,牛和山羊牛奶的N键合金黄色葡萄球菌的抗病毒疗法的比较

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摘要

N-linked oligosaccharides (N-glycans) derived from milk were recently found to be antipathogenic. This study compares the antimicrobial activity of N-linked glycans and free oligosaccharides from human, bovine, and goat milk against Staphylococcus aureus. Milk N-glycans showed a bactericidal/bacteriostatic effect on the pathogen when compared to free milk oligosaccharides, evidenced by the clear zone from the halo assay, with the order of human milk >goat milk >bovine milk. None of the free milk oligosaccharide samples were bactericidal/bacteriostatic, despite its positive results in growth curve and minimum inhibitory concentration (MIC) assays which are believed to be related to hyperosmosis. Both N-glycans and free milk oligosaccharides can reduce the adhesion of Staphylococcus aureus to Caco-2 cells, however, N-glycans worked significantly more effective than free milk oligosaccharides. Structural analysis of all free oligosaccharide and N-glycan samples showed the obvious interspecies differences, and the structure/function relationship of the respected N-glycans is of interest for future study. The significant bactericidal/bacteriostatic activity possessed by human, bovine, and goat milk N-linked glycans holds great potential as a novel substitute for antibiotics.
机译:最近发现衍生自牛奶的N-连接的寡糖(N-聚糖)是抗疟药。该研究比较了N-连接聚糖的抗微生物活性和来自人,牛和山羊牛奶对金黄色葡萄球菌的游离寡糖的抗微生物活性。与游离牛奶寡糖相比,牛奶N-Glycans对病原体表现出杀菌/抑菌效果,从Halo测定的透明区证明,用人乳>山羊牛奶>牛奶。尽管其阳性产生了生长曲线和最低抑制浓度(MIC)测定,但据信的抑制浓度(MIC)测定有关的含有阳性的乳酸寡糖的样品均无阳性结果。 N-聚糖和游离牛奶寡糖均可降低金黄色葡萄球菌对Caco-2细胞的粘附,然而,N-聚糖的工作比游离牛奶寡糖明显更有效。所有游离寡糖和N-甘油样品的结构分析表明,显而易见的差异,尊重的N-Glycans的结构/功能关系对于未来的研究感兴趣。人,牛和山羊牛奶N-连接的聚糖具有显着的杀菌/抑菌活性,具有巨大的抗生素替代品的巨大潜力。

著录项

  • 来源
    《Journal of Food Science》 |2020年第9期|2329-2339|共11页
  • 作者单位

    Glycomks and Glycan Bioengineering Research Center (GGBRC) College of Food Science and Technology Nanjing Agricultural University Nanjing Jiangsu China.;

    Glycomks and Glycan Bioengineering Research Center (GGBRC) College of Food Science and Technology Nanjing Agricultural University Nanjing Jiangsu China.;

    Glycomks and Glycan Bioengineering Research Center (GGBRC) College of Food Science and Technology Nanjing Agricultural University Nanjing Jiangsu China.;

    Glycomks and Glycan Bioengineering Research Center (GGBRC) College of Food Science and Technology Nanjing Agricultural University Nanjing Jiangsu China.;

    Glycomks and Glycan Bioengineering Research Center (GGBRC) College of Food Science and Technology Nanjing Agricultural University Nanjing Jiangsu China. jiangsu Collaborative Innovation Center of Meat Production Processing and Quality Control College of Food Science and Technology Nanjing Agricultural University Nanjing jiangsu China.;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antimicrobial effect; free oligosaccharides; milk N-glycan; Staphylococcus aureus;

    机译:抗微生物效果;免费寡糖;牛奶N-甘草;金黄色葡萄球菌;

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