Uses of 'Good Laboratory Practices' by regulated industry and agencies, and the safety of bisphenol A

摘要

As the argument about the risk of the ubiquitous plastic chemical bisphenol A (BPA) continues,~1 we should recall that every toxic chemical is regulated the same way: with its key safety data supplied by the manufacturer with typically millions to billions of revenue a year riding on that safety question. In fact, for many years no chemical risk assessment (RA) performed for premar-keting safety testing has used any but the data supplied by the chemical's manufacturer, for the key toxicity studies which determine a chemical's alleged low or no observable adverse effect level (1/NOAEL) (nor have many RAs on chemicals already on the market). Hundreds of thousands of peer-reviewed, published findings-of much higher quality than the industry's financially conflicted data-have been ignored.